A Ruthenium(II) <i>N</i>-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway

A Ruthenium(II) <i>N</i>-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway

The p38 MAPK pathway is known to influence the anti-tumor effects of several chemotherapeutics, including that of organometallic drugs. Previous studies have demonstrated the important role of p38 both as a regulator and a sensor of cellular reactive oxygen species (ROS) levels. Investigating the an...

Full description

Bibliographic Details
Main Authors: Yasamin Dabiri, Alice Schmid, Jannick Theobald, Biljana Blagojevic, Wojciech Streciwilk, Ingo Ott, Stefan Wölfl, Xinlai Cheng
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
naphthalimide-metal complex conjugates
<i>N</i>-heterocyclic carbene
mitochondria
ROS
p38 MAPK
apoptosis
cancer
Online Access:https://www.mdpi.com/1422-0067/19/12/3964

Internet

https://www.mdpi.com/1422-0067/19/12/3964

Similar Items