The Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum

The Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum

Drug addiction is a chronic, debilitating disease that affects millions of people around the world causing a substantial societal burden. Despite decades of research efforts, treatment possibilities remain limited and relapse represents the most treatment-resistant element. Neurosteroid sigma-1 rece...

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Bibliographic Details
Main Authors: Anna M. Klawonn, Anna Nilsson, Carl F. Rådberg, Sarah H. Lindström, Mia Ericson, Björn Granseth, David Engblom, Michael Fritz
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Pharmacology
Subjects:
addiction
cocaine
conditioned place preference
sigma-receptor
Siramesine
electrophysiology
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00714/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00714/full

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