The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors
The upstream pathways regulating leukemic transcriptional plasticity for differentiation arrest and resistance to therapy are unclear. Here the authors show that aPKC λ/ι-controls leukemic B-cell precursor differentiation arrest trough RAC/MEK/ERK/SATB2 epigenetic repression
Bibliographic Details
| Main Authors: |
R. C. Nayak,
S. Hegde,
M. J. Althoff,
A. M. Wellendorf,
F. Mohmoud,
J. Perentesis,
M. Reina-Campos,
D. Reynaud,
Y. Zheng,
M. T. Diaz-Meco,
J. Moscat,
J. A. Cancelas |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-07846-y
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