The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors

The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors

The upstream pathways regulating leukemic transcriptional plasticity for differentiation arrest and resistance to therapy are unclear. Here the authors show that aPKC λ/ι-controls leukemic B-cell precursor differentiation arrest trough RAC/MEK/ERK/SATB2 epigenetic repression

Bibliographic Details
Main Authors: R. C. Nayak, S. Hegde, M. J. Althoff, A. M. Wellendorf, F. Mohmoud, J. Perentesis, M. Reina-Campos, D. Reynaud, Y. Zheng, M. T. Diaz-Meco, J. Moscat, J. A. Cancelas
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07846-y

Internet

https://doi.org/10.1038/s41467-018-07846-y

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