A natural-like synthetic small molecule impairs bcr-abl signaling cascades and induces megakaryocyte differentiation in erythroleukemia cells.

Over the past years, we synthesized a series of new molecules that are hybrids of spirocyclic ketones as complexity-bearing cores with bi- and ter-phenyls as privileged fragments. Some of these newly-shaped small molecules showed antiproliferative, pro-apoptotic and differentiating activity in leuke...

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Main Authors: Silvia Turroni, Manlio Tolomeo, Gianfranco Mamone, Gianluca Picariello, Elisa Giacomini, Patrizia Brigidi, Marinella Roberti, Stefania Grimaudo, Rosaria Maria Pipitone, Antonietta Di Cristina, Maurizio Recanatini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3584047?pdf=render