Antimony resistance in Leishmania (Viannia) braziliensis clinical isolates from atypical lesions associates with increased ARM56/ARM58 transcripts and reduced drug uptake

Antimony resistance in Leishmania (Viannia) braziliensis clinical isolates from atypical lesions associates with increased ARM56/ARM58 transcripts and reduced drug uptake

BACKGROUND In addition to the limited therapeutic arsenal and the side effects of antileishmanial agents, drug resistance hinders disease control. In Brazil, Leishmania braziliensis causes atypical (AT) tegumentary leishmaniasis lesions, frequently refractory to treatment. OBJECTIVES The main goa...

Full description

Bibliographic Details
Main Authors: Jeronimo Nunes Rugani, Célia Maria Ferreira Gontijo, Frédéric Frézard, Rodrigo Pedro Soares, Rubens Lima do Monte-Neto
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
antimony resistance
Leishmania braziliensis
field isolates
antimony resistance marker
ARM56
ARM58
atypical lesions
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100344&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100344&lng=en&tlng=en

Similar Items