Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms

DNA damage causally contributes to aging and cancer. Congenital defects in nucleotide excision repair (NER) lead to distinct cancer-prone and premature aging syndromes. The genetics of NER mutations have provided important insights into the distinct consequences of genome instability. Recent work in...

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Bibliographic Details
Main Authors:	Diletta Edifizi, Björn Schumacher
Format:	Article
Language:	English
Published:	MDPI AG 2015-08-01
Series:	Biomolecules
Subjects:	Ultraviolet Light (UV) DNA damage aging Nucleotide-excision repair (NER) Global-genome nucleotide-excision repair (GG-NER) Transcription-coupled nucleotide excision repair (TC-NER) Cockayne syndrome (CS) somatotropic axis growth hormone/insulin-like growth factor 1 (GH/IGF1) signaling longevity
Online Access:	http://www.mdpi.com/2218-273X/5/3/1855

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