Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms

DNA damage causally contributes to aging and cancer. Congenital defects in nucleotide excision repair (NER) lead to distinct cancer-prone and premature aging syndromes. The genetics of NER mutations have provided important insights into the distinct consequences of genome instability. Recent work in...

Full description

Bibliographic Details
Main Authors: Diletta Edifizi, Björn Schumacher
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Biomolecules
Subjects:
Ultraviolet Light (UV)
DNA damage
aging
Nucleotide-excision repair (NER)
Global-genome nucleotide-excision repair (GG-NER)
Transcription-coupled nucleotide excision repair (TC-NER)
Cockayne syndrome (CS)
somatotropic axis
growth hormone/insulin-like growth factor 1 (GH/IGF1) signaling
longevity
Online Access:http://www.mdpi.com/2218-273X/5/3/1855

Internet

http://www.mdpi.com/2218-273X/5/3/1855

Similar Items