Screening for Susceptibility-Related Biomarkers of Diclofenac-Induced Liver Injury in Rats Using Metabolomics

Screening for Susceptibility-Related Biomarkers of Diclofenac-Induced Liver Injury in Rats Using Metabolomics

Early identification of individuals susceptible to idiosyncratic drug-induced liver injury (IDILI) is a challenging unmet demand. Diclofenac, one of the most widely available over-the-counter drugs for pain management worldwide, may induce liver dysfunction, acute liver failure, and death. Herein, w...

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Bibliographic Details
Main Authors: Can Tu, Yuan Gao, Di Song, Ming Niu, Run-ran Ma, Ming-xi Zhou, Xian He, Xiao-he Xiao, Jia-bo Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
idiosyncratic drug-induced liver injury
diclofenac
susceptible individual
metabolomics
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.693928/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.693928/full

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