Glutamate and glutathione interplay in a motor neuronal model of amyotrophic lateral sclerosis reveals altered energy metabolism

Glutamate and glutathione interplay in a motor neuronal model of amyotrophic lateral sclerosis reveals altered energy metabolism

Impairment of mitochondrial function might contribute to oxidative stress associated with neurodegeneration in amyotrophic lateral sclerosis (ALS). Glutamate levels in tissues of ALS patients are sometimes altered. In neurons, mitochondrial metabolism of exogenous glutamine is mainly responsible for...

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Bibliographic Details
Main Authors: Giuseppina D'Alessandro, Eleonora Calcagno, Silvia Tartari, Milena Rizzardini, Roberto William Invernizzi, Lavinia Cantoni
Format: Article
Language:English
Published: Elsevier 2011-08-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Glutathione
Glutamate
Glutamine
Motor neuron
NSC-34 cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111001203

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http://www.sciencedirect.com/science/article/pii/S0969996111001203

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