FOXO1 Confers Maintenance of the Dark Zone Proliferation and Survival Program and Can Be Pharmacologically Targeted in Burkitt Lymphoma

FOXO1 Confers Maintenance of the Dark Zone Proliferation and Survival Program and Can Be Pharmacologically Targeted in Burkitt Lymphoma

The FOXO1 transcription factor plays a central role in the proliferation and survival of B cells at several stages of differentiation. B cell malignancies, with exception of classical Hodgkin lymphoma, maintain expression of FOXO1 at levels characteristic for their non-malignant counterparts. Extens...

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Bibliographic Details
Main Authors: Franziska Gehringer, Stephanie E Weissinger, Lotteke JYM Swier, Peter Möller, Thomas Wirth, Alexey Ushmorov
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
foxo1
burkitt lymphoma
germinal center dark zone b cell proliferation program
Online Access:https://www.mdpi.com/2072-6694/11/10/1427

Internet

https://www.mdpi.com/2072-6694/11/10/1427

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