An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII.

An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII.

Coagulation Factor VIII is activated by an ordered limited thrombin proteolysis with different catalytic efficiency at three P1 Arginine residues: Arg759> Arg1708>Arg391, indicating the flanking residues of the latter to be less optimal. This study aimed to investigate, in silico and in vitro,...

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Bibliographic Details
Main Authors: Behnaz Pezeshkpoor, Ursula Schreck, Arijit Biswas, Julia Driesen, Ann-Cristin Berkemeier, Anna Pavlova, Jens Müller, Johannes Oldenburg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5500338?pdf=render

Internet

http://europepmc.org/articles/PMC5500338?pdf=render

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