Vorinostat eliminates multicellular resistance of mesothelioma 3D spheroids via restoration of Noxa expression.

Vorinostat eliminates multicellular resistance of mesothelioma 3D spheroids via restoration of Noxa expression.

When grown in 3D cultures as spheroids, mesothelioma cells acquire a multicellular resistance to apoptosis that resembles that of solid tumors. We have previously found that resistance to the proteasome inhibitor bortezomib in 3D can be explained by a lack of upregulation of Noxa, the pro-apoptotic...

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Bibliographic Details
Main Authors: Dario Barbone, Priscilla Cheung, Sailaja Battula, Sara Busacca, Steven G Gray, Daniel B Longley, Raphael Bueno, David J Sugarbaker, Dean A Fennell, V Courtney Broaddus
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3530471?pdf=render

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http://europepmc.org/articles/PMC3530471?pdf=render

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