The Antimelanoma Immunocytokine scFvMEL/TNF Shows Reduced Toxicity and Potent Antitumor Activity against Human Tumor Xenografts

The Antimelanoma Immunocytokine scFvMEL/TNF Shows Reduced Toxicity and Potent Antitumor Activity against Human Tumor Xenografts

The immunocytokine scFvMEL/TNF, a fusion protein composed of human tumor necrosis factor (TNF) and a single-chain Fv antibody (scFv) scFvMEL targeting the melanoma gp240 antigen, demonstrates impressive cytotoxic effects against human melanoma cell lines in vitro. Pharmacokinetic studies of 125I-sc...

Full description

Bibliographic Details
Main Authors: Yuying Liu, Weihe Zhang, Lawrence H. Cheung, Ting Niu, Qingping Wu, Chun Li, Carolyn S. Van Pelt, Michael G. Rosenblum
Format: Article
Language:English
Published: Elsevier 2006-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Tumor necrosis factor
melanoma
immunocytokine
single-chain Fv antibody
tumor xenograft
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800588

Internet

http://www.sciencedirect.com/science/article/pii/S1476558606800588

Similar Items