Rhinovirus Infection Is Associated With Airway Epithelial Cell Necrosis and Inflammation via Interleukin-1 in Young Children With Cystic Fibrosis

Rhinovirus Infection Is Associated With Airway Epithelial Cell Necrosis and Inflammation via Interleukin-1 in Young Children With Cystic Fibrosis

Introduction: The responses of cystic fibrosis (CF) airway epithelial cells (AEC) to rhinovirus (RV) infection are likely to contribute to early pathobiology of lung disease with increased neutrophilic inflammation and lower apoptosis reported. Necrosis of AEC resulting in airway inflammation driven...

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Bibliographic Details
Main Authors: Samuel T. Montgomery, Dario L. Frey, Marcus A. Mall, Stephen M. Stick, Anthony Kicic, AREST CF
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
cystic fibrosis
airway epithelium
rhinovirus
interleukin-1
necrosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00596/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00596/full

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