The Cancer Cell Dissemination Machinery as an Immunosuppressive Niche: A New Obstacle Towards the Era of Cancer Immunotherapy

The Cancer Cell Dissemination Machinery as an Immunosuppressive Niche: A New Obstacle Towards the Era of Cancer Immunotherapy

Although cancer immunotherapy has resulted in unpreceded survival benefits to subsets of oncology patients, accumulating evidence from preclinical animal models suggests that the immunosuppressive tumor microenvironment remains a detrimental factor limiting benefit for many patient subgroups. Recent...

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Bibliographic Details
Main Authors: Saeed Asiry, Gina Kim, Panagiota S. Filippou, Luis Rivera Sanchez, David Entenberg, Douglas K. Marks, Maja H. Oktay, George S. Karagiannis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
cancer immunotherapy
tumor microenvironment
endothelial anergy
lymphocyte exclusion
lymphocyte exhaustion
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.654877/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.654877/full

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