In vivo fluctuation of Tax, Foxp3, CTLA-4, and GITR mRNA expression in CD4+CD25+ T cells of patients with human T-lymphotropic virus type 1-associated myelopathy

In vivo fluctuation of Tax, Foxp3, CTLA-4, and GITR mRNA expression in CD4+CD25+ T cells of patients with human T-lymphotropic virus type 1-associated myelopathy

HTLV-1 Tax expression exerts an inhibitory effect on the Foxp3 transcription factor in CD4+CD25+ T-regulatory cells (Treg). For a better understanding of the role of Tax mRNA in the gene expression of cellular markers we measured Tax, Foxp3, CTLA-4, GITR, TGF-β, and IL-10 mRNA in Treg cells...

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Bibliographic Details
Main Authors:	E. Ramirez, L. Cartier, L. Rodriguez, C. Alberti, M.A. Valenzuela
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2010-11-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	HTLV-1-associated myelopathy Tax Foxp3 CTLA-4 GITR mRNA expression
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100014

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