In vivo fluctuation of Tax, Foxp3, CTLA-4, and GITR mRNA expression in CD4+CD25+ T cells of patients with human T-lymphotropic virus type 1-associated myelopathy

In vivo fluctuation of Tax, Foxp3, CTLA-4, and GITR mRNA expression in CD4+CD25+ T cells of patients with human T-lymphotropic virus type 1-associated myelopathy

HTLV-1 Tax expression exerts an inhibitory effect on the Foxp3 transcription factor in CD4+CD25+ T-regulatory cells (Treg). For a better understanding of the role of Tax mRNA in the gene expression of cellular markers we measured Tax, Foxp3, CTLA-4, GITR, TGF-β, and IL-10 mRNA in Treg cells...

Full description

Bibliographic Details
Main Authors: E. Ramirez, L. Cartier, L. Rodriguez, C. Alberti, M.A. Valenzuela
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2010-11-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
HTLV-1-associated myelopathy
Tax
Foxp3
CTLA-4
GITR mRNA expression
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100014

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100014

Similar Items