Antimicrobial Peptide TP4 Induces ROS-Mediated Necrosis by Triggering Mitochondrial Dysfunction in Wild-Type and Mutant <i>p53</i> Glioblastoma Cells

Antimicrobial Peptide TP4 Induces ROS-Mediated Necrosis by Triggering Mitochondrial Dysfunction in Wild-Type and Mutant <i>p53</i> Glioblastoma Cells

Antimicrobial peptide tilapia piscidin 4 (TP4) from <i>Oreochromis niloticus</i> exhibits potent bactericidal and anti-tumorigenic effects. In a variety of cancers, the mutation status of p53 is a decisive factor for therapeutic sensitivity. Therefore, we investigated the impact of <i...

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Bibliographic Details
Main Authors: Bor-Chyuan Su, Chieh-Yu Pan, Jyh-Yih Chen
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cancers
Subjects:
antimicrobial peptide
tilapia piscidin 4
glioblastoma
<i>p53</i>
ROS
DNA damage
necrosis
Online Access:https://www.mdpi.com/2072-6694/11/2/171

Internet

https://www.mdpi.com/2072-6694/11/2/171

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