Efficient one-step production of (<it>S</it>)-1-phenyl-1,2-ethanediol from (<it>R</it>)-enantiomer plus NAD<sup>+</sup>–NADPH <it>in</it>-<it>situ</it> regeneration using engineered <it>Escherichia coli</it>

Efficient one-step production of (<it>S</it>)-1-phenyl-1,2-ethanediol from (<it>R</it>)-enantiomer plus NAD<sup>+</sup>–NADPH <it>in</it>-<it>situ</it> regeneration using engineered <it>Escherichia coli</it>

<p>Abstract</p> <p>Background</p> <p><it>Candida parapsilosis</it> CCTCC M203011 catalyzes the stereoinversion of (<it>R</it>)-1-phenyl-1,2-ethanediol (PED) through oxidation and reduction. Its NAD<sup>+</sup>-linked (<it>R</...

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Bibliographic Details
Main Authors: Zhang Rongzhen, Xu Yan, Xiao Rong, Zhang Botao, Wang Lei
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Microbial Cell Factories
Subjects:
Redox cofactor regeneration
Chiral alcohol
Alcohol dehydrogenases/reductases
Metabolic pathway
One-step stereoinversion
Online Access:http://www.microbialcellfactories.com/content/11/1/167

Internet

http://www.microbialcellfactories.com/content/11/1/167

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