Interaction between genetic predisposition, smoking, and dementia risk: a population-based cohort study

Abstract We evaluated whether the association between cigarette smoking and dementia risk is modified by genetic predisposition including apolipoprotein E (APOE) genotype and polygenic risk (excluding the APOE region). We included 193,198 UK Biobank participants aged 60–73 years without dementia at...

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Bibliographic Details
Main Authors: Na Zhang, Janice M. Ranson, Zhi-Jie Zheng, Eilis Hannon, Zhenwei Zhou, Xuejun Kong, David J. Llewellyn, Daniel A. King, Jie Huang
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-92304-x