A method to address differential bias in genotyping in large-scale association studies.

In a previous paper we have shown that, when DNA samples for cases and controls are prepared in different laboratories prior to high-throughput genotyping, scoring inaccuracies can lead to differential misclassification and, consequently, to increased false-positive rates. Different DNA sourcing is...

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Bibliographic Details
Main Authors: Vincent Plagnol, Jason D Cooper, John A Todd, David G Clayton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1868951?pdf=render