Development and validation of an HPLC–MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study

Development and validation of an HPLC–MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study

Abstract Purpose To develop and validate a bio-analytical HPLC–MS/MS method for the determination of conivaptan (CVA) an arginine-vasopressin receptor blocker in human plasma and in rat liver microsomes (RLMs). Methods Analytes were separated on a reversed phase C18 column (50 mm × 2.1 mm, 1.8 μm)....

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Bibliographic Details
Main Authors: Haitham Alrabiah, Adnan A. Kadi, Mohamed W. Attwa, Gamal A. E. Mostafa
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Chemistry Central Journal
Subjects:
Conivaptan
LC–MS/MS
Human plasma
RLMs
Metabolic stability study
Online Access:http://link.springer.com/article/10.1186/s13065-018-0414-5

Internet

http://link.springer.com/article/10.1186/s13065-018-0414-5

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