N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro

N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro

Highlights • N-terminal truncations promote the soluble expression of HPV L1 proteins in E. coli and their self-assembly of T = 7 icosahedral particle in vitro • An HPV 9-valent vaccine candidate was formulated with E. coli-derived HPV 6, 11, 16, 18, 31, 33, 45, 52, and 58 VLPs, and conferred compar...

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Main Authors: Minxi Wei, Daning Wang, Zhihai Li, Shuo Song, Xianglin Kong, Xiaobing Mo, Yurou Yang, Maozhou He, Zhongyi Li, Bo Huang, Zhijie Lin, Huirong Pan, Qingbing Zheng, Hai Yu, Ying Gu, Jun Zhang, Shaowei Li, Ningshao Xia
Format: Article
Language:English
Published: Taylor & Francis Group 2018-09-01
Series:Emerging Microbes and Infections
Online Access:http://link.springer.com/article/10.1038/s41426-018-0158-2

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http://link.springer.com/article/10.1038/s41426-018-0158-2

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