Homologous recombination occurs frequently at innate GT microsatellites in normal somatic and germ cells in vivo

Homologous recombination occurs frequently at innate GT microsatellites in normal somatic and germ cells in vivo

Abstract Background In somatic cells, homologous recombination (HR) is a rare event caused by eventual DNA double-strand breaks (DSBs). In contrast, germ cells show high frequency of HR caused by programmed DSBs. Microsatellites are prone to DSBs during genome replication and, thereby, capable of pr...

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Bibliographic Details
Main Authors: Jianbo Zheng, Heng Li, Qi Zhang, Lei Sun, Xiangfang Liu, Chen Luo
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Genomics
Subjects:
Homologous recombination
Genome replication
GT microsatellites
Somatic cells
Germ cells
Online Access:http://link.springer.com/article/10.1186/s12864-018-4758-y

Internet

http://link.springer.com/article/10.1186/s12864-018-4758-y

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