Enhancement of Oxytocin in the Medial Prefrontal Cortex Reverses Behavioral Deficits Induced by Repeated Ketamine Administration in Mice

Enhancement of Oxytocin in the Medial Prefrontal Cortex Reverses Behavioral Deficits Induced by Repeated Ketamine Administration in Mice

Ketamine is a popular recreational substance of abuse that induces persistent behavioral deficits. Although disrupted oxytocinergic systems have been considered to modulate vulnerability to developing drugs of abuse, the involvement of central oxytocin in behavioral abnormalities caused by chronic k...

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Bibliographic Details
Main Authors: Weili Zhu, Zengbo Ding, Zhihui Zhang, Xiao Wu, Xiaoya Liu, Ya Zhang, Suxia Li, Liping Zhou, Geng Tian, Jing Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neuroscience
Subjects:
oxytocin
ketamine
medial prefrontal cortex
social avoidance
cognitive impairment
inflammatory mediators
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.723064/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.723064/full

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