<i>Aggregatibacter actinomycetemcomitans</i> Leukotoxin (LtxA; Leukothera<sup>®</sup>): Mechanisms of Action and Therapeutic Applications

<i>Aggregatibacter actinomycetemcomitans</i> Leukotoxin (LtxA; Leukothera<sup>®</sup>): Mechanisms of Action and Therapeutic Applications

<i>Aggregatibacter actinomycetemcomitans</i> is an oral pathogen that produces the RTX toxin, leukotoxin (LtxA; Leukothera<sup>&#174;</sup>). <i>A. actinomycetemcomitans</i> is strongly associated with the development of localized aggressive periodontitis. Ltx...

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Bibliographic Details
Main Authors: Brian A. Vega, Benjamin A. Belinka Jr., Scott C. Kachlany
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Toxins
Subjects:
leukotoxin (LtxA)
RTX (repeats-in-toxin) toxin
<i>Aggregatibacter actinomycetemcomitans</i>
lymphocyte function-associated antigen-1 (LFA-1)
β<sub>2</sub> integrins
cell death
oral microbiology
virulence factor
toxin therapy
Online Access:https://www.mdpi.com/2072-6651/11/9/489

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https://www.mdpi.com/2072-6651/11/9/489

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