Self-Renewal Signalling in Presenescent Tetraploid IMR90 Cells
Endopolyploidy and genomic instability are shared features of both stress-induced cellular senescence and malignant growth. Here, we examined these facets in the widely used normal human fibroblast model of senescence, IMR90. At the presenescence stage, a small (2–7%) proportion of cells overcome th...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2011-01-01
|
| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/103253 |