Beyond the Excluded Volume Effects: Mechanistic Complexity of the Crowded Milieu

Beyond the Excluded Volume Effects: Mechanistic Complexity of the Crowded Milieu

Macromolecular crowding is known to affect protein folding, binding of small molecules, interaction with nucleic acids, enzymatic activity, protein-protein interactions, and protein aggregation. Although for a long time it was believed that the major mechanism of the action of crowded environments o...

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Bibliographic Details
Main Authors: Irina M. Kuznetsova, Boris Y. Zaslavsky, Leonid Breydo, Konstantin K. Turoverov, Vladimir N. Uversky
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Molecules
Subjects:
macromolecular crowding
excluded volume effect
viscosity
soft interactions
solvent properties
aqueous two-phase system
partition
Online Access:http://www.mdpi.com/1420-3049/20/1/1377

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http://www.mdpi.com/1420-3049/20/1/1377

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