Genome-wide mRNA sequencing of a single canine cerebellar cortical degeneration case leads to the identification of a disease associated <it>SPTBN2</it> mutation

Genome-wide mRNA sequencing of a single canine cerebellar cortical degeneration case leads to the identification of a disease associated <it>SPTBN2</it> mutation

<p>Abstract</p> <p>Background</p> <p>Neonatal cerebellar cortical degeneration is a neurodegenerative disease described in several canine breeds including the Beagle. Affected Beagles are unable to ambulate normally from the onset of walking and the main pathological fi...

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Bibliographic Details
Main Authors: Forman Oliver P, De Risio Luisa, Stewart Jennifer, Mellersh Cathryn S, Beltran Elsa
Format: Article
Language:English
Published: BMC 2012-07-01
Series:BMC Genetics
Subjects:
Beta-III spectrin
Beagle dogs
Cerebellar cortical degeneration
Spinocerebellar ataxia type 5
Genome-wide mRNA sequencing
Cerebellum
mRNA-seq
SPTBN2
Canine
Next generation sequencing
Online Access:http://www.biomedcentral.com/1471-2156/13/55

Internet

http://www.biomedcentral.com/1471-2156/13/55

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