6′-O-Galloylpaeoniflorin Attenuates Osteoclasto-genesis and Relieves Ovariectomy-Induced Osteoporosis by Inhibiting Reactive Oxygen Species and MAPKs/c-Fos/NFATc1 Signaling Pathway

6′-O-Galloylpaeoniflorin Attenuates Osteoclasto-genesis and Relieves Ovariectomy-Induced Osteoporosis by Inhibiting Reactive Oxygen Species and MAPKs/c-Fos/NFATc1 Signaling Pathway

Emerging evidence suggests bright prospects of some natural antioxidants in the treatment of osteoporosis. 6′-O-Galloylpaeoniflorin (GPF), an antioxidant isolated from peony roots (one of very widely used Oriental medicines, with various anti-inflammatory, antitumor, and antioxidant activities), sho...

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Bibliographic Details
Main Authors: Wenjie Liu, Gang Xie, Guixin Yuan, Dantao Xie, Zhen Lian, Zihong Lin, Jiajie Ye, Wenyun Zhou, Weijun Zhou, Henghui Li, Xinjia Wang, Haotian Feng, Ying Liu, Guanfeng Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
6′-O-galloylpaeoniflorin
osteoporosis
osteoclast
MAPKs
NFATc1
reactive oxygen species
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.641277/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.641277/full

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