Site-Specific Conversion of Cysteine in a Protein to Dehydroalanine Using 2-Nitro-5-Thiocyanatobenzoic Acid

Dehydroalanine exists natively in certain proteins and can also be chemically made from the protein cysteine. As a strong Michael acceptor, dehydroalanine in proteins has been explored to undergo reactions with different thiolate reagents for making close analogues of post-translational modification...

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Bibliographic Details
Main Authors: Yuchen Qiao, Ge Yu, Sunshine Z. Leeuwon, Wenshe Ray Liu
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/26/9/2619