Angiotensin-converting enzyme (ACE) inhibitory activity of Solanum torvum and isolation of a novel methyl salicylate glycoside

• Main Authors: Arunee Simaratanamongkol, Kaoru Umehara, Hiroki Niki, Hiroshi Noguchi, Pharkphoom Panichayupakaranant
• Format: Article
• Language: English
• Published: Elsevier 2014-11-01
• Series: Journal of Functional Foods
• Subjects: Solanum torvum; Angiotensin converting enzyme; ACE; Methyl salicylate glycoside; Torvumoside; (E)-2,3-Dihydroxycyclopentyl-3-(3′,4′-dihydroxyphenyl) acrylate
• Online Access: http://www.sciencedirect.com/science/article/pii/S1756464614002734
• ISSN: 1756-4646

A methanolic extract from Solanum torvum fruits exhibited inhibitory activity against the angiotensin-converting enzyme (ACE) with an IC50 value of 1.2 mg/mL. On the basis of a bioassay-guided isolation, an ACE inhibitory active compound, namely (E)-2,3-dihydroxycyclopentyl-3-(3′,4′-dihydroxyphenyl)acrylate (1) (IC50 of 778 µg/mL), was obtained, together with a novel methyl salicylate glycoside – torvumoside [methyl salicylate 2-O-(2′-O-β-apiofuranosyl, 6′-O-β-xylopyranosyl)-β-glucopyranoside] (3) and a known compound, lariciresinol-4,4′-O-β-D-diglucoside (2). This is the first report of these compounds in this plant.