Neuronal hibernation following hippocampal demyelination

Neuronal hibernation following hippocampal demyelination

Abstract Cognitive dysfunction occurs in greater than 50% of individuals with multiple sclerosis (MS). Hippocampal demyelination is a prominent feature of postmortem MS brains and hippocampal atrophy correlates with cognitive decline in MS patients. Cellular and molecular mechanisms responsible for...

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Bibliographic Details
Main Authors: Selva Baltan, Safdar S. Jawaid, Anthony M. Chomyk, Grahame J. Kidd, Jacqueline Chen, Harsha D. Battapady, Ricky Chan, Ranjan Dutta, Bruce D. Trapp
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Acta Neuropathologica Communications
Subjects:
Hippocampal demyelination
Long-term potentiation (LTP)
Dendritic spines
Transcript profiling
Online Access:https://doi.org/10.1186/s40478-021-01130-9

Internet

https://doi.org/10.1186/s40478-021-01130-9

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