NF-κB Immunity in the Brain Determines Fly Lifespan in Healthy Aging and Age-Related Neurodegeneration

NF-κB Immunity in the Brain Determines Fly Lifespan in Healthy Aging and Age-Related Neurodegeneration

During aging, innate immunity progresses to a chronically active state. However, what distinguishes those that “age well” from those developing age-related neurological conditions is unclear. We used Drosophila to explore the cost of immunity in the aging brain. We show that mutations in intracellul...

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Bibliographic Details
Main Authors: Ilias Kounatidis, Stanislava Chtarbanova, Yang Cao, Margaret Hayne, Dhruv Jayanth, Barry Ganetzky, Petros Ligoxygakis
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Cell Reports
Subjects:
Drosophila
NF-κB
Imd
Relish
brain
innate immunity
lifespan
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717304825

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http://www.sciencedirect.com/science/article/pii/S2211124717304825

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