Nuclear translocation and regulation of intranuclear distribution of cytoplasmic poly(A)-binding protein are distinct processes mediated by two Epstein Barr virus proteins.

Nuclear translocation and regulation of intranuclear distribution of cytoplasmic poly(A)-binding protein are distinct processes mediated by two Epstein Barr virus proteins.

Many viruses target cytoplasmic polyA binding protein (PABPC) to effect widespread inhibition of host gene expression, a process termed viral host-shutoff (vhs). During lytic replication of Epstein Barr Virus (EBV) we observed that PABPC was efficiently translocated from the cytoplasm to the nucleus...

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Bibliographic Details
Main Authors: Richard Park, Ayman El-Guindy, Lee Heston, Su-Fang Lin, Kuan-Ping Yu, Mate Nagy, Sumit Borah, Henri-Jacques Delecluse, Joan Steitz, George Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3976295?pdf=render

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http://europepmc.org/articles/PMC3976295?pdf=render

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