Knockdown of α2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion

Knockdown of α2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion

Aberrant sialylation is frequently found in pancreatic ductal adenocarcinoma (PDA). α2,3-Sialyltransferases (α2,3-STs) ST3GAL3 and ST3GAL4 are overexpressed in PDA tissues and are responsible for increased biosynthesis of sialyl-Lewis (sLe) antigens, which play an important role in metastasis. This...

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Bibliographic Details
Main Authors: Pedro Enrique Guerrero, Laura Miró, Bin S Wong, Anna Massaguer, Neus Martínez-Bosch, Rafael de Llorens, Pilar Navarro, Konstantinos Konstantopoulos, Esther Llop, Rosa Peracaula
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
pancreatic ductal adenocarcinoma
α2,3-sialyltransferases
sialyl-Lewis antigens
E-selectin
cell migration
Online Access:https://www.mdpi.com/1422-0067/21/17/6239

Internet

https://www.mdpi.com/1422-0067/21/17/6239

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