Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1α

Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1α

Alterations in the expression and activity of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α (ppargc1a or PGC-1α) have been reported in multiple movement disorders, yet it is unclear how a lack of PGC-1α impacts transcription and function of the cerebellu...

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Bibliographic Details
Main Authors: Elizabeth K Lucas, Courtney S. Reid, Laura J. McMeekin, Sarah E. Dougherty, Candace L. Floyd, Rita Marie Cowell
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Ataxia
Cerebellum
Friedreich Ataxia
Refsum Disease
Stereology
PPARGC1A
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00441/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00441/full

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