New Zampanolide Mimics: Design, Synthesis, and Antiproliferative Evaluation

Zampanolide is a promising microtubule-stabilizing agent (MSA) with a unique chemical structure. It is superior to the current clinically used MSAs due to the covalent nature of its binding to <i>&#946;</i>-tubulin and high cytotoxic potency toward multidrug-resistant cancer cells. H...

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Bibliographic Details
Main Authors: Guanglin Chen, Ziran Jiang, Qiang Zhang, Guangdi Wang, Qiao-Hong Chen
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/25/2/362