Cytotoxic Cyplasin of the Sea Hare, Aplysia punctata, cDNA Cloning, and Expression of Bioactive Recombinants in Insect Cells

Cytotoxic Cyplasin of the Sea Hare, Aplysia punctata, cDNA Cloning, and Expression of Bioactive Recombinants in Insect Cells

A 56-kDa protein isolated from the mucus of the European sea hare Aplysia punctata shows a preferential toxicity to autonomously growing transformed mammalian cells. Cell death induced by this protein differs from both apoptosis and necrosis. The cytotoxic effects are irreversible and become appare...

Full description

Bibliographic Details
Main Authors: Christian Petzelt, Gaby Joswig, Hermann Stammer, Dieter Werner
Format: Article
Language:English
Published: Elsevier 2002-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
antitumor
recombinant
melanoma
secretion signal
GFP
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558602800471

Internet

http://www.sciencedirect.com/science/article/pii/S1476558602800471

Similar Items