Leucine-Rich Glioma Inactivated 1 Promotes Oligodendrocyte Differentiation and Myelination via TSC-mTOR Signaling

Leucine-Rich Glioma Inactivated 1 Promotes Oligodendrocyte Differentiation and Myelination via TSC-mTOR Signaling

Leucine-rich glioma inactivated 1 (Lgi1), a putative tumor suppressor, is tightly associated with autosomal dominant lateral temporal lobe epilepsy (ADLTE). It has been shown that Lgi1 regulates the myelination of Schwann cells in the peripheral nervous system (PNS). However, the function and underl...

Full description

Bibliographic Details
Main Authors: Ya-Jun Xie, Lin Zhou, Yin Wang, Nan-Wei Jiang, Shenglong Cao, Chong-Yu Shao, Xin-Tai Wang, Xiang-Yao Li, Ying Shen, Liang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Lgi1
myelination
oligodendrocyte
oligodendrocyte precursor cell
mTOR
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00231/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00231/full

Similar Items