Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain

Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain

<p>Abstract</p> <p>Background</p> <p>The CCR2/CCL2 system has been identified as a regulator in the pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia and the mechanism underlying antinociception produced by CCR2 antagonists remains po...

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Bibliographic Details
Main Authors: Vaillancourt François, Lembo Paola MC, Lessard Etienne, Jomphe Claudia, Martino Giovanni, Elmes Steven JR, McIntosh Fraser, Paré Michel, Serrano Alexandre, Perkins Martin N, Cao Chang
Format: Article
Language:English
Published: SAGE Publishing 2010-12-01
Series:Molecular Pain
Online Access:http://www.molecularpain.com/content/6/1/90

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http://www.molecularpain.com/content/6/1/90

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