Reduced postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse

Reduced postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse

Duchenne muscular dystrophy (DMD) is caused by the absence of a functional transcript of the protein dystrophin. DMD is associated with a range of cognitive deficits that are thought to result from a lack of the protein dystrophin in brain structures involved in cognitive functions. The CNS involvem...

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Bibliographic Details
Main Authors: S.L.L. Kueh, J. Dempster, S.I. Head, J.W. Morley
Format: Article
Language:English
Published: Elsevier 2011-09-01
Series:Neurobiology of Disease
Subjects:
Duchenne muscular dystrophy
Dystrophin
Purkinje cell
Cerebellum
GABAA receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111001562

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http://www.sciencedirect.com/science/article/pii/S0969996111001562

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