Epigenetic Regulation of the Biosynthesis & Enzymatic Modification of Heparan Sulfate Proteoglycans: Implications for Tumorigenesis and Cancer Biomarkers

Epigenetic Regulation of the Biosynthesis & Enzymatic Modification of Heparan Sulfate Proteoglycans: Implications for Tumorigenesis and Cancer Biomarkers

Emerging evidence suggests that the enzymes in the biosynthetic pathway for the synthesis of heparan sulfate moieties of heparan sulfate proteoglycans (HSPGs) are epigenetically regulated at many levels. As the exact composition of the heparan sulfate portion of the resulting HSPG molecules is criti...

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Bibliographic Details
Main Authors: Elizabeth E. Hull, McKale R. Montgomery, Kathryn J. Leyva
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:International Journal of Molecular Sciences
Subjects:
biomarkers
biosynthetic pathways
enzymatic modification
epigenetic regulation
glycosylation
heparan sulfate proteoglycans
lectin arrays
sulfation
Online Access:http://www.mdpi.com/1422-0067/18/7/1361

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http://www.mdpi.com/1422-0067/18/7/1361

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