Myeloperoxidase-Derived 2-Chlorohexadecanal is Generated in Mouse Heart during Endotoxemia and Induces Modification of Distinct Cardiomyocyte Protein Subsets In Vitro

Myeloperoxidase-Derived 2-Chlorohexadecanal is Generated in Mouse Heart during Endotoxemia and Induces Modification of Distinct Cardiomyocyte Protein Subsets In Vitro

Sepsis is a major cause of mortality in critically ill patients and associated with cardiac dysfunction, a complication linked to immunological and metabolic aberrations. Cardiac neutrophil infiltration and subsequent release of myeloperoxidase (MPO) leads to the formation of the oxidant hypochlorou...

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Bibliographic Details
Main Authors: Jürgen Prasch, Eva Bernhart, Helga Reicher, Manfred Kollroser, Gerald N. Rechberger, Chintan N. Koyani, Christopher Trummer, Lavinia Rech, Peter P. Rainer, Astrid Hammer, Ernst Malle, Wolfgang Sattler
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
click chemistry
electrophile damage
fatty acids
hypochlorous acid
myeloperoxidase
proteomics
Online Access:https://www.mdpi.com/1422-0067/21/23/9235

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https://www.mdpi.com/1422-0067/21/23/9235

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