Regulation of cisplatin-resistant head and neck squamous cell carcinoma by the SRC/ETS-1 signaling pathway

Regulation of cisplatin-resistant head and neck squamous cell carcinoma by the SRC/ETS-1 signaling pathway

Abstract Background We investigated the role of the ETS-1 transcription factor in Head and Neck Squamous Cell Carcinoma (HNSCC) in multiple cisplatin-resistant HNSCC cell lines. Methods We examined its molecular link with SRC and MEK/ERK pathways and determined the efficacy of either MEK/ERK inhibit...

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Bibliographic Details
Main Authors: Zejia Yang, Jipei Liao, Brandon A. Carter-Cooper, Rena G. Lapidus, Kevin J. Cullen, Hancai Dan
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Cancer
Subjects:
Head and neck squamous cell carcinoma
HNSCC
ETS-1
Cisplatin resistance
SRC
MEK/ERK
Online Access:http://link.springer.com/article/10.1186/s12885-019-5664-7

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http://link.springer.com/article/10.1186/s12885-019-5664-7

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