Modifications of sodium channel voltage dependence induce arrhythmia-favouring dynamics of cardiac action potentials.

Heart arrhythmia is a pathological condition where the sequence of electrical impulses in the heart deviates from the normal rhythm. It is often associated with specific channelopathies in cardiac tissue, yet how precisely the changes in ionic channels affect the electrical activity of cardiac cells...

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Bibliographic Details
Main Authors: Pia Rose, Jan-Hendrik Schleimer, Susanne Schreiber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0236949