A new KSRP-binding compound suppresses distant metastasis of colorectal cancer by targeting the oncogenic KITENIN complex

A new KSRP-binding compound suppresses distant metastasis of colorectal cancer by targeting the oncogenic KITENIN complex

Abstract Background Distant metastasis is the major cause of death in patients with colorectal cancer (CRC). Previously, we identified KITENIN as a metastasis-enhancing gene and suggested that the oncogenic KITENIN complex is involved in metastatic dissemination of KITENIN-overexpressing CRC cells....

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Bibliographic Details
Main Authors: Jeong A Bae, Woo Kyun Bae, Sung Jin Kim, Yoo-Seung Ko, Keon Young Kim, So-Yeon Park, Young Hyun Yu, Eun Ae Kim, Ik Joo Chung, Hangun Kim, Hyung-Ho Ha, Kyung Keun Kim
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Molecular Cancer
Subjects:
Colorectal cancer
KITENIN complex
KSRP
Metastasis
microRNA
Online Access:https://doi.org/10.1186/s12943-021-01368-w

Internet

https://doi.org/10.1186/s12943-021-01368-w

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