Genomic Features and Clinical Management of Patients with Hereditary Pancreatic Cancer Syndromes and Familial Pancreatic Cancer

Genomic Features and Clinical Management of Patients with Hereditary Pancreatic Cancer Syndromes and Familial Pancreatic Cancer

Pancreatic cancer (PC) is one of the most devastating malignancies; it has a 5-year survival rate of only 9%, and novel treatment strategies are urgently needed. While most PC cases occur sporadically, PC associated with hereditary syndromes or familial PC (FPC; defined as an individual having two o...

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Bibliographic Details
Main Authors: Akihiro Ohmoto, Shinichi Yachida, Chigusa Morizane
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
hereditary cancer syndrome
Lynch syndrome
familial pancreatic cancer
next-generation sequencing
germline mutation
surveillance
PARP inhibitor
immune checkpoint inhibitor
Online Access:https://www.mdpi.com/1422-0067/20/3/561

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https://www.mdpi.com/1422-0067/20/3/561

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