The Reactions of H<sub>2</sub>O<sub>2</sub> and GSNO with the Zinc Finger Motif of XPA. Not A Regulatory Mechanism, But No Synergy with Cadmium Toxicity

The Reactions of H<sub>2</sub>O<sub>2</sub> and GSNO with the Zinc Finger Motif of XPA. Not A Regulatory Mechanism, But No Synergy with Cadmium Toxicity

Tetrathiolate zinc fingers are potential targets of oxidative assault under cellular stress conditions. We used the synthetic 37-residue peptide representing the tetrathiolate zinc finger domain of the DNA repair protein XPA, acetyl-DYVICEECGKEFMSYLMNHFDLPTCDNCRDADDKHK-amide (XPAzf) as a working mod...

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Bibliographic Details
Main Authors: Aleksandra Witkiewicz-Kucharczyk, Wojciech Goch, Jacek Olędzki, Andrea Hartwig, Wojciech Bal
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
zinc fingers
zinc
cadmium
hydrogen peroxide
S-nitrosoglutathione
oxidation
Online Access:https://www.mdpi.com/1420-3049/25/18/4177

Internet

https://www.mdpi.com/1420-3049/25/18/4177

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